BIO152H5 Lecture Notes - Lecture 11: Endomembrane System, Signal Peptide, Color Blindness

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16 Aug 2020
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Biology lecture 11 chapter 17 continued. Often translation is not sufficient to make a functional protein. Polypeptide chains are modified after translation or targeted to specific sites in the cell. During and after synthesis, a polypeptide chain begins to spontaneously coil and fold into its three- dimensional shape. A gene dictates primary structure, and primary structure determines shape. Proteins may require post-translational modifications before becoming fully functional. Some activated by enzymes that cleave them. Other polypeptides come together to form protein subunits. Two populations of ribosomes are evident in cells: Free ribosomes mostly synthesize proteins that function in the cytosol. Bound ribosomes make proteins of the endomembrane system and proteins that are secreted from cell. The ribosomes are identical and can switch from free to bound. The signal mechanism for targeting proteins to the er. Polypeptide synthesis always begins in the cytosol. Synthesis finishes in cytosol unless polypeptide signals ribosome to attach to er.

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