PSY 3142 Lecture Notes - Lecture 22: Tolcapone, Catechol-O-Methyl Transferase, Reuptake

• School: University of Ottawa
• Department: Psychology
• Course: PSY 3142
• Professor: Philip Wall

Document Summary

Dopamine pathways: mesolimbic a ects positive symptoms, mesocortical cognitive and negative symptoms, nigostriatal motor side e ects, tuberhypophyseal regulates pituitary hormone secretion; neuroendocrine e ets. Side e ects: parkinsonism: a motor side e ect that resembles symptoms of parkinson"s disease. Parkinson"s is caused by loss of cell bodies in the substantia nigra, which gives rise to the nigostriatal pathway. Lack of da function in the stratum increases cholinergic cell activity, which causes the motor e ects. Parkinsons disease is treated by reducing excess acetylcholine activity. Neuroleptic drugs that have with anti-cholinergic action, such as thioridazinezine has been developed. Td increases with duration of treatment: neuroendocrine e ects include decreased sex drive, no mensturation, increased prolactin, and inhibition of growth hormone release. Weight gain and inability to regulate body temperature are also problematic: neuroleptic malignant syndrome (nms) is serious and life-threatening.