HSS 3106 Lecture Notes - Lecture 8: Mania, Tyramine, Headache

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 3106
• Professor: Ron Saulnier

Document Summary

Lecture 8: drugs and the nervous system part 2. Nervous system disorder characterized by movement abnormalities such as tremor of head and extremities, difficulty coordinating fine muscle movement, hypokinesia (inability or slowness in initiating movements) Substantia nigra is important to initiation and control of muscular movement. Lack of dopaminergic activity in substantia nigra leads to imbalance between dopamine and acetylcholine. Dopamine-producing cells in the brainstem are lost. Dopamine works closely with acetylcholine, which runs the balance and homeostasis of the two which affect balance and movement (mood and behaviour, etc. ) The four primary symptoms of pd are: tremor, or trembling in hands, arms, legs, jaw, and face, rigidity, or stiffness of the limbs and trunk, bradykinesia, or slowness of movement, postural instability, or impaired balance and coordination. A lot of acetylcholine and not enough dopamine. Pharmacotherapy attempts to rebalance dopamine and acetylcholine by: You can only increase the dopamine so much. Replacing the dopamine is the most common treatment.