HSS 1100 Lecture Notes - Lecture 5: Gas Gangrene, Exotoxin, Enterotoxin

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 1100
• Professor: Franco Pagotto

Document Summary

Spore forming rods: bacillus and clostridium, release of potent exotoxins cause disease. Prevention and treatment: rapid treatment is essential, antibiotics: penicillin, doxycycline, ciprofloxacin or levofloxacin, vaccine against pa protein is available. Bacillus cereus: causes food poisoning when spores enter food product, motile, non-encapsulated, resistant to penicillin, enterotoxin is responsible for illness, 2 types of enterotoxin, heat labile: nausea, abdominal pain, diarrhea. Last 12-24hrs: heat stable: severe nausea and vomiting, short incubation, a(cid:374)ti(cid:271)ioti(cid:272)s treat(cid:373)e(cid:374)t useless prefor(cid:373)ed to(cid:454)i(cid:374)s. Clostridium: anaerobic differentiates this bacteria from other spore-forming bacilli, botulism, tetanus, gas gangrene and pseudomembranous colitis, powerful exotoxins repid diagnosis. Infant botulism: honey contamination with spores, spores germinate and bacteria colonizes intestine, neurotoxin release, 2-3 days of constipation trouble swallowing, muscle weakness clinical manifestations of clostridium botulinum. Non-spore forming rods: 2 medically important bacilli listeria monocytogenes and corynebacterium diptheriae. Corynebacterium diphtheria: causative agent of diphtheria.