HSS 1100 Lecture Notes - Lecture 3: Gamma Globulin, Genitourinary System, Rheumatoid Arthritis

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 1100
• Professor: Franco Pagotto

Document Summary

Immunity = the protection against infectious disease conferred either by the immune response ge(cid:374)erated (cid:271)(cid:455) i(cid:373)(cid:373)u(cid:374)izatio(cid:374) or pre(cid:448)ious i(cid:374)fe(cid:272)tio(cid:374) or (cid:271)(cid:455) other (cid:374)o(cid:374)i(cid:373)(cid:373)u(cid:374)ologi(cid:272) fa(cid:272)tors a. k. a (cid:271)od(cid:455)"s a(cid:271)ilit(cid:455) to resist i(cid:374)fe(cid:272)tio(cid:374) 2 types of immunity: non-specific (innate, specific (adaptive, acquired) Mucous membranes (mechanical: cilia in respiratory tract, lysozymes, ph. Iron-binding proteins: some bacteria require iron for growth, transferrin, lactoferrin. Innate: protects against any invader, does not discriminate: adaptive: directed against one type of invader, dependant on past exposure. Antibody: protein that binds specifically to a substance (its antigen) Igs or immunoglobulins: produced by b-lymphocytes upon stimulation from antigen presenting t-cells, recognize toxins, capsules, some viral proteins. Ig produced in response to stimulation by an antigen and reacting specifically with it: disti(cid:374)guish (cid:862)(cid:374)o(cid:374)-self(cid:863) fro(cid:373) (cid:862)self(cid:863, constant and variable region. Variable region is responsible for antigen recognition. Antigen: (cid:862)(cid:374)o(cid:374)-self(cid:863, protein, glycoprotein, lipoprotein, polysaccharide. 5 classes: igg, iga, igm, ige, igd. Igg: host defense, crosses placenta and protects newborn.