BPS 2110 Lecture Notes - Lecture 5: Lone Pair, Lipophilicity, Hydrogen Bond

• School: University of Ottawa
• Department: Biopharmaceutical sciences
• Course: BPS 2110
• Professor: Robert Ben

Document Summary

Same forces we use to dissolve a solute in a solvent. By looking at forces, you can determine if drug will bind to target. Make a designer solvent (uses same forces in same way as drug binding to target) Insulating effect, attraction for pos and neg get much stronger when in grease bc it removes the dilution. Negatively charged group is often acid sometimes phosphates. Doesn"t matter which compound (drug/target) has the positive or neg charge just as long as they are complimentary. When on upside it can be surrounded by solvent and weakens the bond. Water is very polar and can solvate pos and negative ions. Adding a second attraction which reduces the attraction of positive and neg charge. If there"s a binding pocket in the target and drug can go inside pocket to exclude water there is a strong attraction. The only thing a pos charge can do is attract to the neg charge.