BIOLOGY 445 Lecture Notes - Lecture 6: Prescription Drug, Amoxicillin, Kidney Disease
18 Sep 2017
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Pharmacology lecture 6- pharmacodynamics: explain the pharmacologic concept of a receptor and providing several examples. Therapeutic and toxic effects of drugs result from their interactions with molecules in the patient. Most drugs act by associating with a specific macromolecule in ways that alter the macromolecules biochemical or biophysical activates. The receptor is the component of a cell or organism that interacts with a drug and initiates the chain of events leading to the drugs observed effects. Some examples of drug receptors are beta blockers with beta-adrenoreceptors, clozapine with dopamine receptors: explain how a drug interacts with a receptor. A drug can interact with a receptor by: covalent bonds, non-covalent bonds- cation interactions, electrostatic forces, hydrophobic effect, van der waals bonds, hydrogen bonds, steric complementarity- racemic mixtures, stereoisomers (one form active/one inactive, drug design: pharmacophore * Drug (ligand), and receptor form a complex. Kd= [ligand][receptor]/[complex] how tight the drug and receptor bind. Produce a lower response, at full receptor occupancy.
