BPS 1101 Lecture Notes - Lecture 2: Naphthalene, Threshold Of Pain, Cytochrome C Oxidase Subunit I

• School: University of Ottawa
• Department: Biopharmaceutical sciences
• Course: BPS 1101
• Professor: William Ogilvie

Document Summary

Prescripion drugs: billion/year (u. s), worldwide billion. Over the counter: billion/year, 10x smaller market, cheaper, top otc are cough and cold, pain, antacid, toothpaste, laxaives: pain relievers most common otc drug . 7 billion/year o. Side efects: all drugs have side efects, 2 things to know, the efect and the incidence (harder to ind) Counter-indicaions: when you shouldn"t use it (condiions, combinaions, foods, natural remedies) Salix (genus including willow, poplar, beech, wintergreen) have salicylates naturally. Reverend stone (1702-1768), doctrine of signatures, tasted willow bark in the forest. Quinine treats fever, is biter, willow is biter so it must cure fever!! Henri leroux (1829) extracted salicin, the acive ingredient from the bark (1. 5 kg 30 g salicin) Rafaelle piria 1838 converted salicin to salicylic acid. Analgesic: for pain, anipyreic for fever, ani-inlammatory for swelling. Natural way 1. 5 kg bark 30 g salicin 14 g salycilic acid. Syntheic 1 kg coal tar kolbe schmit rxn 300 g salicylic acid.