BIO 4120 Lecture Notes - Lecture 3: Peromyscus, Acclimatization, Carotid Body
Document Summary
Title: control of breathing and ventilatory acclimatization to hypoxia in deer mice native to high altitudes. Highlanders had a more effective breathing pattern characterized by deeper but less frequent breaths during acute hypoxia compared to lowlanders. High-altitude deer mice exhibited a more effective breathing pattern than low-altitude deer mice, characterized by deeper but less frequent breaths during acute hypoxia challenge. Deer mice (peromyscus maniculatus) that inhabit high altitudes and congeneric mice that inhabit low altitudes (peromyscus leucopus) were bred in captivity at sea level. Their offsprings were raised to adulthood and then acclimated to normoxia or hypobaric hypoxia (12 kpa, simulating hypoxia at ~4300 m) for 5 months. Responses to acute hypoxia were then measured during stepwise reductions in inspired o2 fraction.
