BIO 3303 Lecture Notes - Lecture 16: Caldesmon, Swim Bladder, Skeletal Muscle

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Intercalated disks: contact point btw cardiomyocytes gap junctions: all cells contract almost all at once. Branched in between are plates; those discs have gap junctions so electrical signals are passed quickly. Message gets sent to all cells almost exactly at the same time. Hr set by activity of the sinoatrial (sa) node (pacemaker: ap spreads via gap junctions and causes contraction of heart, regulated by sympathetic and parasympathetic innervation. Sa node depolarizes depolarization spreads via internodal pathways to av node: depolarization spreads through atria via gap junctions, atria contracts. Depolarization spreads through the bundles of his and purkinje fibers then upward cell to cell via gap junctions: ventricle contracts. Need to be unified as a team. They have to contract at the same time to release and push out that volume. Using the sa node the heart is myogenic group of cells with characteristics that allow it to depolarize on itself.

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