BIO 3170 Lecture Notes - Lecture 1: Phosphodiester Bond, Bacteriophage, Cdk5R1
4 Nov 2016
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The two experiments suggesting genes are made of dna. Dna is composed of sugar, base, and phosphate; base is attached at c1; ring is part of phosphodiester bond; c5 is connected to phosphodiester bond; c4 carries c5. Pyrimidines: thymine, cytosine, uracil---methyl group on c5 differentiates thymine and uracil; In the formation of the double helix, base is in the center; important bc the bases will produce force to form the structure (include all atoms, charges, double bonds, etc. when drawing the structure) Nucleotide ought to (cid:271)e flipped (cid:449)he(cid:374) dra(cid:449)i(cid:374)g stru(cid:272)tures . How does double helix form?-water is most important where dna forms bc of hydrogen bonds; Lynus pauling suggested 3 strand helix(which was wrong); watson-crick generated correct structure; we were taught dna had no water, but dna is never dry and what dictates double helix structure is water. Water maximises the number of h-bonds double helix can form. Conclusion: water dictates the structure of the dna double helix.
