BIO 3153 Lecture Notes - Lecture 19: Adenylyl Cyclase, Membrane Transport Protein, Ryanodine
29 Aug 2016
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Document Summary
Ca2+ signaling: there are 3 primary mechanisms by which ca2+ can be released from intracellular stores, the first two have been previously discussed, 1. Depolarization-induced ca2+ release (skeletal muscle contraction: 2. Ca2+ signaling: ca2+ signaling can produce local changes in intracellular ca2+, this regulating activity of a small number of other cells, ca2+ signals may involve global elevation of cytosolic ca2+ Ca2+ binding of calmodulin: calcium can bind directly to some proteins, ca2+ binding proteins that relay a signal by interacting with a protein, helps to transduce a calcium signal. Ca2+ falls to 10-7m: calmodulin can lead to its own inactivation by reducing ca2+ concentration, steps, 1. 2 ca2+ ions may bind at each of the 2 hand regions of calmodulin. Aspartic and glutamic acid side chains: 2. Conformational change activates ca-calmodulin complex, exposes binding sites: 3. Globular hands bind to calmodulin binding sites of target protein to modify its activity (functional change)
