BIO 3147 Lecture Notes - Lecture 6: Microrna, B Cell, Model Organism
Document Summary
Different ways that you can regulate expression at different level. In the anterior region there is a bicoid that is keeping the gene from being expressed, it needs to be removed in the posterior region. Lin-4 is a microrna (functional rna) and lin-14 is a protein. A microrna gene expresses an rna transcript that is not translated but it does form hair pin structures that are cut into individual hair pins. The messenger rna is always a copy of the sense strand and this lin-4 can either shut down translation by not allowing ribosomes to bind or by cutting the mrna. The lymphoid precursor cell can generate b cells or t cells. For the lymphoid to become a b cell or t cell, it needs different types of microrna. You can drive your lymphoid cells artificially to become what you want by adding more of the certain kinds of microrna.
