BIO 3124 Lecture Notes - Lecture 12: Microbiological Culture, Microtubule, Botulism
Document Summary
Control of microbial growth: in vivo (antibiotherapy: antimicrobial drugs, antibiotic or antibacterial: against bacteria, antifungal: against fungi, antiviral: against viruses, the drugs: antibiotics. Old de nition: any compound made by a microorganism which inhibits or kills bacteria. New de nition: any compound which inhibits or kills bacteria. High selective toxicity: must kill or inhibit the targeted organism with minimal deleterious effects on the host. Ie. penicillin: targets cel wall > high selective toxicity. Ie. cyanide: targets electron transport of eukaryotes/prokaryotes > low selective toxicity. High toxic or lethal dose (ld50): concentration of the agent that is toxic for the host. Low therapeutic dose: concentration of the agent required for the clinical treatment of an infection. Class of antibiotic that has a beta lactic ring. Inhibit cell wall synthesis (replication: growing and diving cells) Penicillins and cephalosporins: natural penicillin: penicillin g. Narrow spectrum: only acts on gram positives: aminopenicillin: ampicillin and amoxicillin.
