BIO 3124 Lecture Notes - Lecture 11: Cephalosporin, Viral Disease, Antibiotics
7 Dec 2016
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Document Summary
If the invading microorganism does not develop a resistance it will die. 1945 - a. fleming warns that the inappropriate sue of penicillin will lead to the selection of resistant bacteria. A few years later the first resistant strains appear. The number of resistant bacteria is increasing at an alarming rate. 1990: 300 metric tons of antibiotics are used in humans. Prescribed for bacterial infections which would have resolved themselves. Antibiotherapy is less expensive than other tests and treatments -> much cheaper than culturing. Resistance is not acquired; natural trait --> independent of a selective pressure. Streptomycetes are resistant to the antibiotics they produce. Gram negative bacteria : lps layer acts as a permeability barrier. Some bacteria do not possess the antibiotic"s target. Mycoplasms - no cell wall; therefore resistant to penicillin and cephalosporin. Mycobacteria - no peptidoglycan; therefore resistant to penicillin and cephalosporin. The microorganism acquires a resistance to one or more antibiotics.
