BIO 3124 Lecture 13: TOPIC 13 VIRSUSES WITHIN EVERYONES REACH
24 Nov 2016
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Lecture 13 - viruses within everyone"s reach (416) Human papilloma, influenza and the human immunodeficiency virus. Types 6, 11, 16 and 18 are the most common. Rna dependent dna pol. and dna dependent dna pol. Allows integration of viral genome into cellular genome. Maturation of polyproteins by protease gag, pol and env gag capsid proteins pol reverse transcriptase and integrase env gp120 and gp41. Adv: if drug enters infected cell it will activate, if it enters noninfected cell. Several antivirals are prodrugs (inactive form of the drug) They must be phosphorylated by viral enzymes to be activated. Must have an acceptable toxicity for the host. No viral drugs which are absolutely non toxic to humans. Created to inhibit functions which are essential to the viral infectious cycle. Current antivirals have no effect on viruses which are not reproducing! Acts on infectious cycle not the virus itself. A host immune response is essential for recovery from a viral infection.
