BIO 2133 Lecture Notes - Lecture 4: Foxp2, Peptide, Intron
26 Oct 2014
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Document Summary
Gene: the fundamental physical unit of heredity, whose existence can be confirmed by allelic variants and which occupies a specific chromosomal locus. A dna sequence coding for a single polypeptide we do not isolate genes, we see their frequency. Foxp2- identified by a family in ke in london, speech impediment (half of the family had speech disorders) Dominant condition ( seen in every generation) Phenotypic test: imaging of the brain broca"s area is an area of the brain that processes thought and goes to speech centre so one can speak. Affected individuals" broca"s area does not light up, something is wrong with that area. Identification of foxp2 chromosome 7, region 7q31 (problem in the development of speech) Foxp2 protein is a transcription factor: dna transcription, initiation: proteins will bind to the promoter (open the double strand molecule for the binding of the rna polymerase.
