BIO 1140 Lecture Notes - Lecture 13: Threonine, Inositol Trisphosphate, Gluconeogenesis
22 Jul 2016
School
Department
Course
Professor
Document Summary
When the ligand binds to the receptor. As soon as the ligand binds to it, the monomorers each bind a ligand and dimerize. The receptor has to autophosphorelate in order for the receptor to become active. Grb2 and sos are needed to interact with sos. Sos and grb2 are needed because ras and the receptor are like puzzle pieces that don"t fit. In order to be able to interact with the phosphorelated tyrosenes, the protein needs a specific domain/ shape. Ras does not have the proper shape to interact with any of the phosphorylated tyrosenses. Grb2 is able to interact with the receptor but not ras. Sos is able to interact with grb2, but not the receptor. So you stack them together in order to relay the the information to the amplification enzyme. The amplification comes because when ras is activated, it will be able to transfer the information to more than one target.
