BIO 1140 Lecture Notes - Lecture 5: Growth Factor, Adenylyl Cyclase, Grb2

• School: University of Ottawa
• Department: Biology
• Course: BIO 1140
• Professor: Caroline Petit- Turcotte

Document Summary

Action potential triggers the opening of a calcium channel while moving towards the terminal end. The acl is secreted by exocytosis from a vesicle. The acl diffuses across the two cells in which it binds to a receptor on the motor end of the sarcellema. Once reached the sarcellema cation channels open and sodium enters as potassium exits the cell. This causes a polarized portion of the cell opening na2+ channels and reducing the threshold of the action potential. This then leads to the action potential flow of the muscle tissue. Initiation of cascades cause phosphorolation/dephosphorolation that amplifies the cascade enzymatic activity. Binding of the hormone causes dimerization and autophosphorolation of the tyrosines in which the structure now has a particular structure in which it can interact. The binding of grb2 and sos coupled receptors occurs, causing ras to be able to communicate with the receptor.