BIO 1140 Lecture Notes - Lecture 23: Intracellular Ph, Plasmodesma, Ras Subfamily
5 Mar 2018
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Thu, april 7-lecture 23 end of cell cycle. G0 is controlled by a protein called p53. We need to be able to prevent that cell (in g0) from ever entering g1. P53 is responsible for triggering apoptosis (intrinsic apoptosis). At the same time as it is triggering apoptosis, p53 also triggers numerous micrornas. Rnas are genes that are activated and lead to an mrna (a very short mrna - hence the "micro") is part of a protein complex that is looking for mrnas that are headed to translation. If the match is perfect, directly send to degredation. If the match is not perfect, they hold on to them (still prevents translation from occurring). You are sending the cell to apoptosis, don"t need to be translating proteins because you"re getting ready to kill the cells off. Micrornas are triggered alongside initiating the apoptotic pathway.
