BIO 1140 Lecture Notes - Lecture 10: Cdk Inhibitor, Cyclin E, Anaphase-Promoting Complex

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indigomoose336

17 Apr 2017

School

University of Ottawa

Department

Biology

Course

BIO 1140

Professor

Caroline Petit- Turcotte

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Document Summary

Overview of the cell cycle and its control https://www. ncbi. nlm. nih. gov/books/nbk21466/ Dna synthesis, but these factors cannot induce dna synthesis in a g2 nucleus: the isolation of yeast cell-division cycle (cdc) mutants led to the identification of genes that regulate the cell cycle. Cdk6 cyclin d function in mid to late g1; cdk2 cyclin e in late g1; cdk2 cyclin a in s; and cdk1 cyclin a and. Cdk1 cyclin b in g2 and m through anaphase (see figure 13-29): growth factors induce expression of early-response genes, many of which encode transcription factors that stimulate expression of delayed-response genes. The cell-cycle control system is based on cyclically activated protein kinases: the cell-cycle control system is a family cyclin-dependent kinases (cdks). Cdk active site causes conformational change that increases the activity of cdk, allowing the kinase to phosphorylate its target proteins effectively and thereby induce specific cell-cycle events.

Related Questions

31.????? interphase A. cytoplasm divided between the two daughter cells

32.????? chromosomenumber B. final phase of mitosis; daughter nuclei form

33.????? chromatid C. sum total of chromosomes in all cells of a given

type

34.????? cytokinesis D. chromosomes condense and mitotic spindle

begins to form

35.????? metaphase E. chromosomes line up at spindle equator

36.????? alleles F. sister chromatids separate, move to opposite

spindle poles now

37.????? prophase G. none between meiosis I and II

38.????? telophase H. half of a chromosome in prophase

39. ????? anaphase I. different molecular forms of the same gene

Matching

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Question 3 (5 points)

Match the terms to the definitions provided.

Question 3 options:

	telophase II
	meiosis II
	telophase I
	anaphase I
	anaphase II

1.	Division, beginning without DNA replication, that resembles and produces four haploid cell.s
2.	Phase of meiosis when chiasmata are broken as spindle fibers shorten and homologous pairs are pulled apart.
3.	Phase of meiosis when sister chromatids are pulled to opposite poles of the cells.
4.	Phase of meiosis in which homologues cluster at the poles of the cells and the nuclear envelope reforms.
5.	Phase of meiosis in which four different haploid cells are present.

Question 4 (7 points)

Match the terms to the definitions provided.

Question 4 options:

	G0
	telophase
	G2
	mitosis
	cytokinesis
	cell cycle
	S

1.	The phase in which the cell synthesizes a replica of its genome
2.	The overall process of genome duplication
3.	The phase in the cell cycle during which mitochondria and other organelles replicate.
4.	The phase in mitosis when chromosomes are clustered at opposite poles and the spindle apparatus disappears
5.	A resting state that cells often enter before resuming cell division.
6.	The phase in the cell cycle when the cytoplasm divides creating two daughter cells.
7.	The phase in the cell cycle in which the spindle apparatus assembles and sister chromatids move apart.

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Question 5 (6 points)

Put the events of a MAP kinase cascade in the correct order.

Question 5 options:

	MAPKKK phosphorylates and activates another kinase
	MAPKK phosphorylates and activates MAPK
	Binding of MAPKKK to Ras
	External signal binds to membrane receptor and activates receptor kinase.
	MAPK phosphorylates an inactive response protein and activates it.
	Phosphorylation of receptor kinase and interaction with RAS