BIO 1140 Lecture Notes - Lecture 5: Intermediate Filament, Tubulin, Microtubule

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Slide 3: blue is nucleus, green is tubulins, red is actin filaments. Functions of the cytoskeleton: provide cell with structure and support, aids in intracellular transport (movement of organelles, vesicles, positions organelles within cell. Way of scaffolding anchors organelles: ge(cid:374)erates for(cid:272)e to help the (cid:272)ell (cid:373)o(cid:448)e, to (cid:272)ha(cid:374)ge (cid:272)ell"s shape/size as it gro(cid:449)s, aids in cell division (mitosis) Each dimer is made of 2 tubulin subunits (alpha and beta tubulins) Microtubules are hollow tubes: found in cytoplasm, near er; cover most of the interior inside the cell but, (cid:373)i(cid:272)rotu(cid:271)ule (cid:374)et(cid:449)ork do(cid:374)"t e(cid:454)te(cid:374)d all the (cid:449)a(cid:455) to the plas(cid:373)a (cid:373)e(cid:373)(cid:271)ra(cid:374)e (however, microfilaments do extend all the way: microtubules do not cut across organelles, anchored from the same starting point (centrosome, orga(cid:374)ize (cid:272)ell"s i(cid:374)terior. They have no dire(cid:272)tio(cid:374)s, so the(cid:455) do(cid:374)"t go a(cid:374)(cid:455)(cid:449)here. Thus intermediate filaments are not used for transport for anything. Cilia and flagella are made the same way, but flagella are much longer.

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