BCH 2333 Lecture Notes - Lecture 16: Non-Coding Rna, Wobble Base Pair, Hoogsteen Base Pair

• School: University of Ottawa
• Department: Biochemistry
• Course: BCH 2333
• Professor: Adam Jason Shuhendler

Document Summary

Backbone is made up of highly negatively charged phosphate esters. Unlike dna, rna has a single ribose sugar. Rna has a 2" hydroxyl group (dna does not) Most often rna is happy existing as a single strand. Since rna has the extra hydroxyl it tends to prefer the c3" endo. When we are talking about tertiary structures, we are generally talking about non-coding rna. Non-coding rna doesn"t have to form a b-helix. Rna uses all three types of base-pairing: hoogesteen, watson-crick, sugar edge. Non-coding rna is non-informational: it has other functions such as enzyme signaling. It becomes an active participant in the biochemistry of the cell. It doesn"t need the same degree of fidelity as dna, therefore it doesn"t matter how many mutations it has, it is just the structure we are worried about. Angles between base and sugar are different from each-other, and also they are different from the.