ANP 1105 Lecture Notes - Lecture 7: Polycythemia Vera, Vasospasm, Hematopoietic Stem Cell

• School: University of Ottawa
• Department: Anatomy and Physiology
• Course: ANP 1105
• Professor: William Staines

Document Summary

Colour is scarlet (o2-rich) to dark red (o2-poor) 8% body weight (5-6 l men; 4-5 l women) Only fluid tissue in body (formed elements suspended in plasma) Plasma proteins (produced in liver (except gamma globulins); functional proteins which remain in blood) Albumin 60% of all plasma proteins); carrier of various molecules, important blood buffer; major osmotic protein. Has biconcave disc shape, is anucleate, and essentially has no organelles. Contain plasma membrane protein spectrin and other protein. Spectrin forms pentagonal or hexagonal arrangements, forming a scaffolding and playing an important role in maintenance of plasma membrane integrity and cytoskeletal structure. Filled with hemoglobin (hb) for gas transport. Three features make for efficient gas transport: Small size concave shape offers huge sa:v ratio for gas exchange. Hb makes up 97% of cell volume (not counting h2o) Atp production is anaerobic, so they do not consume o2 they transport. # of rbc major factor contributing to blood viscosity.