PHRM 311 Lecture Notes - Lecture 19: Acetyl Group, Nucleus Accumbens, Reinforcement
Document Summary
19. 2 pharmacological actions of common drugs associated with sud (part 2) Alcoholics recover because they want to treat themselves. 10-20% never relapse after first serious attempt to quit. External reminders that drinking is bad disulfiram, peptic ulcer. Source of inspiration, hope, self-esteem alcoholics anonymous, religion. Will power not the whole answer; need to build a new life and learn how to satisfy ways of meeting life"s challenges. Depresses excitatory transmission blocks nmda receptor mediated excitation throughout the cns. Da release in the reward center of the brain. Inhibit gabaergic transmission in the vta, thereby disinhibiting (i. e. activating) vta neurons release da in the nucleus accumbens activate reward processes. Inhibit release of glutamate (excitatory neurotransmitter) from nerve terminals that act on neurons in the nucleus accumbens. Cb1 activity changes in da, gaba, glutamate activity. Ach in the vta, with a subsequent increase in da in the nucleus accumbens positive reinforcement drive.
