PHRM 211 Lecture Notes - Lecture 27: Frontotemporal Lobar Degeneration, Cerebral Cortex, Beers Criteria
Document Summary
Dementia an umbrella term that covers many physical causes of cognitive decline. Frontotemporal lobar degeneration (relates to atrophy of certain parts of the brain) Vascular (arises from lack of blood flow, e. g. stroke) Other causes (brain injury, tumor, alcohol abuse) Alzheimer"s neuropathology: cortex shrivels up, hippocampus shrinkage, ventricles grow larger (increase in fluid, appearance of: Clump together to form amyloid plaques neuroinflammation. Amyloid : metabolic waste products present in the fluid between brain cells. Abnormal aggregation of the tau proteins formation of tangles within nerve cells degeneration of neurons. Tau proteins : help lengthen and support microtubule structures. Cognitive impairment that is sufficient to interfere with adl and functioning. Progressive, deteriorating illness, where treatment is based on the stage of the illness. Differs from mild cognitive impairment, where it does not interfere with independence in activities of daily living. Adults > 65 years old affected the most.
