PHRM 211 Lecture Notes - Lecture 24: Substantia Nigra, Urinary Incontinence, Neurodegeneration
Document Summary
Basal ganglia group of structures that is specifically related to movement. Substantia nigra where we see death of da neurons (50%) Dopamine helps to transfer info from motor command centers. When we don"t have it classic motor symptoms. Parkinson"s disease (pd: therapeutics of parkinson"s disease (part 1) Autonomic dysfunction (excess sweating, erectile dysfunction, constipation, urinary incontinence) rest and digest, instead of fight or flight. Older adults (3% in patients >80 y/o, 1% in patients >65 y/o) Rigidity or bradykinesia as first symptom (instead of tremor) Unclear role of the parkin ( park2 ) gene mutation in this gene found in 8. 6% of patients with early-onset pd. Degeneration of da neurons in substantia nigra dopamine depletion motor symptoms. Postural instability (smaller steps, shuffles, arm not swinging) Autonomic dysfunction (orthostatic hypotension, erectile dysfunction, constipation, urinary incontinence) Skin evaluate for facial dermatitis, which may be seen in pd. Decreased blink rate (increased sense of staring) can be an early sign.
