PHRM 211 Lecture Notes - Lecture 24: Progressive Supranuclear Palsy, Balance Disorder, Essential Tremor
Document Summary
More complications over time as we progress from early to advanced. Early postural instability, autonomic dysfunction, early and prominent dementia, impaired eye movements, rapid progression and poor response to dopaminergic therapy are not features of early pd if present suggest a different diagnosis. Parkinson"s disease presence of bradykinesia with at least 1 other cardinal symptom. Essential tremor tremor with action and absent at rest. Definition: clinical syndrome with motor features (bradykinesia, rigidity, resting tremor) found in or similar to pd. Possible causes: pd, vascular, multiple systems atrophy, dementia, drug-induced. Taking a medication history is key ask about both current and past symptoms. Typically symmetrical and can be any of resting tremor, bradykinesia, or rigidity. Antipsychotics (high risk = haloperidol; low risk = clozapine, quetiapine) Help diagnose idiopathic pd in patients with parkinsonian syndromes. Montreal cognitive assessment (moca) and mini-mental state exam (mmse) Cognitive assessment moca is more sensitive than mmse.
