PHRM 211 Lecture Notes - Lecture 25: Paroxysmal Supraventricular Tachycardia, Supraventricular Tachycardia, Atrial Fibrillation
Document Summary
Iv bolus: inhibits av nodal conduction (less effects on sa) 1st choice for conversion of paroxysmal supraventricular tachycardia to sinus rhythm (high efficacy 90-95%), very short duration of action (~10 s) Less effective in presence with adenosine receptor blockers (e. g. theophylline, caffeine) Side effects : flushing, sob, chest burning ( 10% patients), af. Contraindication : grade ii & iii av block, atrial fibrillation or flutter, obstructive lung diseases. Cardiac glycosides : supraventricular tachycardia, atrial fibrillation and flutter; standby medication. Reduced intracellular k+ levels hyperpolarization conduction velocity. Vagotonic actions inhibition of ca2+ current in av node. Ca2+ exceeds storage capacity of endoplasmic reticulum extrasystoles. Side effects : low therapeutic index, arrhythmia, disturbances of cognitive functions, nausea, blurred vision, hyperkalemia. Magnesium : very effective in prevention of recurrent episodes of torsade-de-pointe arrhythmia & digitalis-associated arrhythmia. Mode of action unknown , also effective in patients with normal mg2+ serum levels. Side effects : flush, bradycardia, hypotension, impaired av conduction.
