PHRM 211 Lecture Notes - Lecture 19: Rhinorrhea, Pertussis, Paroxysmal Attack
Document Summary
Bacteria remain on the surface of airways ( do not invade tissues) Bacteria produces toxins which paralyze respiratory cell cilia. 12% mortality in infants < 6 months old. In adults and older children, usually not serious can give to younger children. Contact with nasal or oral droplets from another human with pertussis. Long inspiratory effort (with high pitched whoop) Do no affect duration of pertussis or severity of disease. Decrease in whoops per day of -3. 1. Kids > 7 years old, less severe disease. Give to patient"s direct contacts before they develop signs and symptoms. Does not change course of disease within a community if there is an outbreak. Shared confined space in close proximity (household, day care, office) for 1 hour. Respiratory, oral/nasal secretion exposure (kissing, being coughed or sneezed upon) Infant <6 mo 10 mg/kg po daily x 5 days. 10 mg/kg po x 1, then 5 mg/kg po daily x 4 days.
