PHRM 111 Lecture Notes - Lecture 23: Haemophilus Influenzae, Hepatitis B Virus, Hib Vaccine
Document Summary
Diphtheria cervical adenopathy, pharyngitis; bacteria (via nasal droplets) Tetanus lock jaw , muscular contraction; slow onset ; anaerobic bacteria. Pertussis whooping cough ; toxins paralyze respiratory cilia; bacteria. *catarrhal stage (1-2 weeks): symptoms of a cold. *paroxysmal stage (1-6 weeks): bursts of coughs, vomiting ; intermittent. Old cellular pertussis: seizures & hypotonic-hyporesponsive episodes. Poliomyelitis enterovirus, 3 serotypes, git, motor neurons (spinal cord & cns) 50% survivors paralyzed impact knee joint/growth (bent leg, limping) Indigenous disease in na eradicated through immunization. 1952 outbreak: whole ward of patients with iron lungs. 1955: salk inactivated vaccine (ipv), booster doses required, europe. 1963: sabin live attenuated oral vaccine, sugar cube x 3 doses, stool (6 weeks), na. 1987: eipv enhanced potency inactivated polio, improved efficacy. Bacteria (gram -ve); does not cause influenza (=influenza virus), via nasal droplets. Common cause of: bacterial meningitis , epiglottitis, pneumonia, bacteremia (kids) >59 months (5 yrs): natural immunity, revaccination not required.
