PHRM 131 Lecture Notes - Lecture 4: Surrogate Endpoint, Systematic Review, Hazard Ratio
Document Summary
Systematic review : a method for systematically locating, appraising and synthesizing research from primary studies. It is an important means of condensing the research evidence from many primary studies. Health literature > literature reviews > systematic review. Meta-analyses is a subset of both systematic and literature reviews. Can determine magnitude of treatment effect & precision of estimate. Often used when you don"t have the definitive trial (not big enough or looked primarily at surrogate endpoints) can put together several small trials. Pull together diverse data types on a topic to characterize results. Ordinal (including measurement scales) e. g. rank, order (agree, disagree) All rcts have point estimate and confidence interval . May be hard to visualize which ones are statistically significant or not (overlap 1). Sequential meta-analysis : take the first study done and add results to it from studies done after (accumulate data)
