MICB 202 Lecture Notes - Lecture 3: Adaptive Immune System, Lymph Node, Mhc Class Ii

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21 Jul 2017
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Proteins are a key component in both of these organisms (as well as other types of molecules) Bacteria and viruses also have pamps which are recognized by the tlrs (get danger signal) For lipids and carbohydrates: non-protein antigen covalently couple to a protein molecule. One set of b cells recognizes the protein part, a different set of b cells recognize the non-protein part. Goals: depending on the class of the antibodies, the can: Block the bacteria (or its toxins) from binding to host cell (neutralization) Activation complement to mac to kill bacteria. Because there was a cut in the skin, the anatomical barrier has been breached. Recruitment of neutrophils and monocytes to site of infection. P(cid:396)odu(cid:272)tio(cid:374) of (cid:862)ala(cid:396)(cid:373) (cid:272)ytoki(cid:374)es(cid:863) (cid:271)y (cid:396)eside(cid:374)t macrophages to start induced innate responses. Phagocytosis of bacteria by macrophages and dendritic cells. (inflammatory response) Resident mast cells (histamine) results in dilation of blood vessels.

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