BIOL 201 Lecture Notes - Lecture 32: Lyase, Transferase, 2-Step Garage
Document Summary
Pyruvate dehydrogenase reaction (pdh) pyruvate conversion to acetyl-coa. 5 cofactors are required (4 made from vitamins). They contribute to 4 processes to convert pyruvate to acetyl-coa: c-c bond cleavage (carbon stabiliza forms carbanion (need internal resonance stabilization or extra cofactor) When no extra cofactor: metal cation (e. g. zinc: acyl group transfer. Cofactor: coa (coenzyme a: production of hei. To produce: nadh for oxidative phosphorylation, acetyl coa for tca cycle. Step 1 involves the decarboxylation of pyruvate . similar to ethanol fermentation step 1. Fadh 2 produced here cannot be used by the etc to generate protons for atp production. Fadh 2 is an enzyme-bound electron donor / prosthetic group ( insoluble carrier) It can only feed into the etc when it is bound by an etc complex. Tricarboxylic acid cycle (tca) aka kreb"s cycle or citric acid cycle. As the cycle continues, 2c are released as co 2.
