MBB 321 Lecture 10: Lecture 10 - Citric Acid Cycle And Glyoxylate Cycle

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Lecture 10: citric acid cycle and glyoxylate cycle. Pyruvate can form acetyl coa, however acetyl coa cannot form pyruvate. Pyruvate is oxidized to acetyl-coa and co2 by the pyruvate dehydrogenase (pdh) complex, which is a cluster of. Enzymes located in the mitochondria of eukaryotic cells (cytosol of bacterial cells). The overall reaction catalyzed by pyruvate dehydrogenase complex is an irreversible oxidative decarboxylation. Reaction, in which the carboxyl group is removed from pyruvate as a molecule of co 2 and the two remaining. The pyruvate dehydrogenase complex contains five major cofactors: thiamine pyrophosphate (tpp, flavin adenine dinucleotide (fad) functions as an electron acceptor (carrier), nicotinamide adenine dinucleotide (nad) functions as an electron acceptor (carrier), coenzyme a (coa, lipoate. Coenzyme a (coa) contains pantothenic acid and a reactive thiol group (-sh) which is critical for the. Function of coa as an acyl carrier in a number of metabolic reactions. Acyl groups are covalently linked to the thiol group forming thioesters,

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