BCCB2003 Lecture Notes - Lecture 9: Hydrolysis, Malate Dehydrogenase, Oxaloacetic Acid

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1 Aug 2018
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Week nine: pyruvate dehydrogenase complex and citric cycle. Three stages of cellular respiration: stage 1: oxidation of organic fuel molecules to produce acetyl coa, glucose pyruvate co-enzyme a, stage 2: acetyl group is oxidised in citric cycle to produce carbon dioxide, nadh, and. Fadh2: stage 3: oxidation of nadh and fadh2, electrons transferred to oxygen as a final acceptor of the electrons, free energy realised is harnessed to phosphorylate adp to atp, water is produced, where most atp is made. Cellular locations of metabolic pathways: glycolysis, cytosol of cells, pyruvate dehydrogenase complex, mitochondrial matrix, oxidative phosphorylation: Needs specific transporters to allow substances to cross this membrane. Even things as small as protons won"t get across without the help of a transporter: forms cristae: Increases surface area: outer membrane, permeable to most things: Net reaction: oxidative decarboxylation of pyruvate (oxidation + removal of carbon atoms, results in the first carbon of glucose being fully oxidised to produce carbon dioxide.

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