BIOL 155 Lecture Notes - Lecture 16: Nephron, Hypoparathyroidism, Kidney Stone Disease

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30 Oct 2018
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Ubc biol 155 lecture 14 notes endocrine system. The parathyroid glands are small in size and are found on the posterior aspect of the thyroid gland. Typically, there are four of them but the actual number may vary. The endocrine cells within these glands are arranged in thick, branching cords containing oxyphil cells of unclear function and most importantly large numbers of chief cells that secrete parathyroid hormone (pth) Pth, a small protein, is the single most important hormone controlling calcium homeostasis. Its release is triggered by falling blood calcium levels and inhibited by hypercalcemia (high blood calcium) There are three target organs for pth: Pth release has the following consequences on these target organs: osteoclasts (bone absorbing cells) are stimulated to digest bone and release ionic, the skeleton, the kidneys, the intestine calcium and phosphates to the blood. Kidneys are stimulated to: reabsorb calcium, excrete phosphate. Absorption of calcium by the intestine increases.

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