BIOL130 Lecture 2: Unit 5 Gene Expression.docx
27 Feb 2015
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Document Summary
Rna = extra oxygen in ribose sugar, single stranded, uracil (instead of thymine) Trna = adaptors between mrna and amino acids. Rrna = form core ribosome & catalyze protein synthesis. Other small rna = rna splicing, telomere maintenance & many other processes. Dna = missing oxygen in deoxy ribose sugar, double stranded. Formation of phosphodiester bonds = hydrogen bonds between base pairs. Exergonic hydrolysis atp (only requires h2o) drives rna synthesis. Non-template/coding strand/sense strand: sequence of dna that matches rna except there are t instead of u. Continuous/leading strand = 3" to 5" = with replication fork. Lagging strand = 5" to 3" hard for polymerase to read. However, both exons and introns are transcripted together. Splicesomes: snrnp"s (ribozyme rna catalytic activity) = cut out splicing of introns as lariat loop (cut of sugar-phosphate backbone to form covalent bond with ribose) Create different proteins from same gene/primary dna. -tropomyosin w/ actin = isoforms have different function.
