ZOO 3050 Lecture Notes - Lecture 17: Sonic Hedgehog, Neural Crest, Surface Ectoderm
5 Feb 2018
School
Department
Course
Professor
Document Summary
Review: signalling pathways, cell shape changes, how do the cells behave during gastrulation and neural plate development, induced by cytoskeletal changes, neural tube next to notochord. Cellular changes in neural tube development: the neural ectoderm overlies the notochord, folding of the neural ectoderm will result in a neural tube, precursor for brain and spinal cord. Closure: epidermal cells will push the edges together, tube folds around hinge points (last lecture, sealed edges to make a closed tube, cells at the edge of the tube are being released, neural crest. Notochord formation: chordamesoderm, gives rise to head processes and notochord. If you have no chordomesoderm you get ectoderm that becomes epidermis, therefore it is the induction of the notochord that . The cells closest to the notochord differentiate into floor plate neurons and then they can later be induced as notochord cells.
