PATH 3610 Lecture Notes - Lecture 5: Coagulative Necrosis, Necrosis, Angiogenesis

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Refers to the state of being diseased or unhealthy within a population: the state of being subject to death. More scar tissue, less functional cells being replaced through proliferation and stem cell differentiation. Myocardial necrosis proceeds invariably to scar formation without any significant regeneration scar tissue will develop after. Suppression of endothelial proliferation & migration, and deposition of the basement membrane. The cells meet in the midline beneath the surface scab, yielding a thin but continuous epithelial layer: neutrophils have been largely replaced by macrophages, and granulation tissue progressively invades the incision space. Collagen fibres are now evident at the incision margins, but these are vertically oriented and do not bridge the incision. Epithelial cell proliferation continues, yielding a thickened epidermal covering layer: neovascularization reaches its peak as granulation tissue fills the incisional space. Collagen fibrils become more abundant and begin to bridge the incision. Cell or tissue loss is more extensive, such as:

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