PATH 3610 Lecture Notes - Lecture 5: Ethylene Glycol, Nephron, Metabolic Acidosis
16 Jun 2017
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Document Summary
Resolution: return to normal after uncomplicated acute inflammation. More parenchymal (functional cells of tissue) lost: regeneration and/or scarring, necrotic cells & inflammatory debris removed. Replacement of necrotic parenchymal cells by new parenchymal cells. Surviving cells adjacent to lost parenchymal may undergo division to replace. Extent of regeneration depends on ability of cell type to divide, number of surviving cells, and whether or not there is surviving connective tissue for normal structure. Epithelial cells, hematopoietic cells of bone marrow. Divide actively throughout life, replace cells normally lost. Tissue injury rapid regeneration from basal germinative layers of epithelial or stem. Parenchymal cells of solid organs (liver, kidney, pancreas, etc ), fibroblast, endothelial. Reversibly postmitotic intermitotic phase for years, but divide if necessary, regenerate. Only healed by scarring functional cells cannot be replaced. Cyclins are primary motivators for cell replication. Interact w/ cyclin-dependent kinases within nucleus, control entry & progression of cells throughout cell cycle.
