NUTR 4010 Lecture Notes - Lecture 21: Total Iron-Binding Capacity, Ferritin, Transferrin

• School: University of Guelph
• Department: Nutrition
• Course: NUTR 4010
• Professor: Dalia El Khoury

Document Summary

Lactating women, pregnant women, smokers, or painter at sea levels. Heavy smokers have higher levels of hb & hct because of the oxidation stress. Mcv & mch are always lower than normal when hemoglobin & hematocrit are lower. False: some cases where you have low hb but the shape or size is not affected. Low serum ferritin, low mch, normal serum b12. Microcytic anima iron-deficiency anemia 3rd stage low ferritin low hb. Holotranscobalamin ii= is related to b12 (decrease reflects b12 deficiency) Plasma homocysteine= b12 or folate (increases with folate or b12 deficiency) Fep= available more with iron deficiency (increases with iron deficiency) Tibc= iron deficiency (increases with iron deficiency, more sites are available to bind iron) Transferrin saturation= (decrease with iron deficiency, less transferrin. How you can get information about iron deficiency in 3rd world countries. Sensitivity: serum levels only decrease when body reserves of vit. Specificity: low are be affected by other factors, such as infection and inflammation.