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MICR 2420 Lecture 14: Lecture 14 Immune Response

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pinkcheetah941
12 May 2017
School
University of Guelph
Department
Microbiology
Course
MICR 2420
Professor
Lucy Mutharia

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Document Summary

Its job is to produce cytokines to help cells do their jobs or activate them. If you do(cid:374)"t do this it (cid:272)a(cid:374) (cid:272)ause i(cid:374)fla(cid:373)(cid:373)atio(cid:374) Some na ve t-cells differentiate into regulatory t-cells (t-reg) Lack of t-reg cells is associated with chronic inflammation. Immunological specifity is important: an antibody made to one epitope will not bind another epitope (unless that epitope is very similar) Ige is the same for all humans but different from eg. that of monkeys. Idiotypes = differences in the hypervariable regions within an individual. Is a monomer with 2 antigen - binding sites. Iga: major secreted antibody of mucosal surfaces, most commonly found as a dimer, linked by disulfide bonds to the j (joining)- chain protein. Secretory piece is wrapped around both molecules during secretion. Secretory iga is found in tears, breast milk and on mucosal surfaces.

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Related Questions

Please briefly explain reasoning for all questions.

1)

Which of the following is a component of a vertebrate kidney? (Select all correct choices.)
glomerulus
Bowman's capsule
renal tubules
collecting ducts
Malphigian tubules

2)

In organisms, the ability to control osmosis depends on the properties of the plasma membranes of individual cells. Based on their ability to permit the free movement of water and some solutes, these membranes are best described as: (select all correct choices)
impermeable.
permeable.
semipermeable.
diffusible.
impervious.

3)

True or false: The inner cell mass of the blastocyst becomes the embryo, while the outer cell layer of the blastocyst forms part of the placenta.
true
false

4)

Which of the following accurately characterizes the early cleavage divisions in most animals, although not necessarily in mammals?
They do not involve an increase in the size of the zygote.
They are directed by the zygote’s genome.
They are relatively slow.
They do not occur at the same time, so at any given moment the zygote may have an odd number of cells.
All of these choices are correct.

5)

A key difference between hormonal regulation of the reproductive systems of males and females is that:
LH and FSH are released only in females.
LH and FSH are released only in males.
LH and FSH are released cyclically in females but nearly continuously in males.
LH is released in males and FSH is released in females.
LH is released continuously in males and FSH is released cyclically in females.

6)

Compared to sexual reproduction, asexual reproduction: (select all correct choices)
requires less investment in attracting mates.
allows much more rapid population growth.
is rarely found as the sole mechanism of reproduction.
results in the production of genetically identical cells or individuals.
involves meiosis and fertilization as core processes.

7)

True or false: In response to LH and FSH, ovaries secrete estrogen and progesterone.
true
false

8)

During the luteal phase of the menstrual cycle, if the oocyte is not fertilized, a number of events occur which are listed below. Select the answer that places the events in the correct chronological order.

Events:
1. the lining of the uterus is shed
2. the corpus luteum secretes progesterone
3. follicle cells are converted to the corpus luteum
4. the corpus luteum degenerates
5. estrogen and progesterone levels fall

3, 2, 4, 5, 1

1, 2, 3, 4, 5

2, 4, 3, 1, 5

4, 3, 2, 1, 5
5, 2, 3, 4, 1

9)

If an antibody is missing its Fc fragment, what would happen if this antibody encounters its target antigen in the bloodstream? Select all correct choices.
The antibody would be able to bind the antigen at a specific epitope.
The antibody would be able to bind the antigen, but not at an epitope site.
The antibody would not be able to bind to the antigen.
The antibody would be able to activate components of the complement system.
The antibody would not be able to activate components of the complement system.

10)

If an individual carries a mutation that results in a complete lack of MHC class I proteins, how would the individual’s immune response be affected? Select all correct choices.
Memory cell antibodies would not be able to attach to antigen epitopes.
Cytotoxic T cells would not be able to target (and destroy) infected cells.
Helper T cells would not be able to interact with antigen-presenting cells.
Plasma cell antibodies would not be able to attach to antigen epitopes.

11)

If an individual carries a mutation that results in a complete lack of MHC class I proteins, how would the individual’s immune response be affected? Select all correct choices.
Memory cell antibodies would not be able to attach to antigen epitopes.
Cytotoxic T cells would not be able to target (and destroy) infected cells.
Helper T cells would not be able to interact with antigen-presenting cells.
Plasma cell antibodies would not be able to attach to antigen epitopes.

12)

Which of the following statements is true regarding T cell receptors? Select all correct choices.
They recognize antigen-MHC complexes.
They contain variable and constant regions.
They are composed of two heavy (H) chains and two light (L) chains.
They are formed by the rearrangement of V, J, C, and D gene segments.
They can be found in the bloodstream independent of T cells.
1) Which of the following is a component of a vertebrate kidney? (Select all correct choices.)
glomerulus
Bowman's capsule
renal tubules
collecting ducts
Malphigian tubules

2)

In organisms, the ability to control osmosis depends on the properties of the plasma membranes of individual cells. Based on their ability to permit the free movement of water and some solutes, these membranes are best described as: (select all correct choices)
impermeable.
permeable.
semipermeable.
diffusible.
impervious.

3)I selected cortex; inner medulla, it was wrong.

The loops of Henle create a concentration gradient in the interstitial fluid surrounding the loop, with the concentration highest in the ____________ and lowest in the ____________ of the kidney.
inner medulla; cortex
outer medulla; inner medulla
outer medulla; cortex
cortex; inner medulla
cortex; outer medulla

4)

The main solutes in the filtrate as it enters the distal convoluted tubule are: (select all correct choices)
urea.
electrolytes.
other wastes.
amino acids.
nucleotides.

5) Ensure all correct choices are selected, for this question I only selected osmosis and it was wrong,

Water moves by: (select all correct choices)
random molecular motion.
active transport.
passive transport.
osmosis.
facilitated diffusion

6)

Compared to sexual reproduction, asexual reproduction: (select all correct choices)
requires less investment in attracting mates.
allows much more rapid population growth.
is rarely found as the sole mechanism of reproduction.
results in the production of genetically identical cells or individuals.
involves meiosis and fertilization as core processes.

7)

A key difference between hormonal regulation of the reproductive systems of males and females is that:
LH and FSH are released only in females.
LH and FSH are released only in males.
LH and FSH are released cyclically in females but nearly continuously in males.
LH is released in males and FSH is released in females.
LH is released continuously in males and FSH is released cyclically in females.

8)

True or false: In response to LH and FSH, ovaries secrete estrogen and progesterone.
true
false

9)

During the luteal phase of the menstrual cycle, if the oocyte is not fertilized, a number of events occur which are listed below. Select the answer that places the events in the correct chronological order.

Events:
1. the lining of the uterus is shed
2. the corpus luteum secretes progesterone
3. follicle cells are converted to the corpus luteum
4. the corpus luteum degenerates
5. estrogen and progesterone levels fall
3, 2, 4, 5, 1
1, 2, 3, 4, 5
2, 4, 3, 1, 5
4, 3, 2, 1, 5
5, 2, 3, 4, 1

10)

If an antibody is missing its Fc fragment, what would happen if this antibody encounters its target antigen in the bloodstream? Select all correct choices.
The antibody would be able to bind the antigen at a specific epitope.
The antibody would be able to bind the antigen, but not at an epitope site.
The antibody would not be able to bind to the antigen.
The antibody would be able to activate components of the complement system.
The antibody would not be able to activate components of the complement system.

11)

If an individual carries a mutation that results in a complete lack of MHC class I proteins, how would the individual’s immune response be affected? Select all correct choices.
Memory cell antibodies would not be able to attach to antigen epitopes.
Cytotoxic T cells would not be able to target (and destroy) infected cells.
Helper T cells would not be able to interact with antigen-presenting cells.
Plasma cell antibodies would not be able to attach to antigen epitopes.

12)

Which of the following statements is true regarding T cell receptors? Select all correct choices.
They recognize antigen-MHC complexes.
They contain variable and constant regions.
They are composed of two heavy (H) chains and two light (L) chains.
They are formed by the rearrangement of V, J, C, and D gene segments.
They can be found in the bloodstream independent of T cells.

HI HELP PLEASE I NEED ANSWERS TO ALL QUESTIONS PLEASE THANKS

1. during inflamation fluid will passively diffuse out of blod vessels into the nearby infected tissue. This implies all of the following EXCEPT

a.the osmolarity of the fluid surrounding infected tissues is higher than the plasma b the surrounding tissue will swell with excessive fluids c near by cappilaries have become more pearmeable d B-lymphocyte will differeniate to become plasma cell

2. which of the following best describe the qualities of most antigens?

a macromolecules that are foreign to the host b atomic elements that are not normally present in the human body c macromolecules tah tare produced by the host organism d atomic elements that are harmful or toxic

3. an adbantages to adaptive immunity is

a its memory cell that provide quicker larger and more efficient immune response upon second exposure to an antigen b its need for several cells to be activated over several days on first exposure c the ability for its individul cells to respond to many differnt pathogens d the use of antibodies that cause cells lysis and kill invading cells

4, an advantages of innate immunity is

a its a barrier taht prevent pathogens from entering into the body b the specifcity of its individual cell which specialize in the removal on one type of antigen c the numerous step in the activation of its cell that can prevent autoimmune disease d the use of the antibodies to cause cell lysis and kill invading cell

5. B- lymphocytes are categorized as part of the adaptive branch of the immune sys for all of the following reason but one Which of the following is NOT one part of reason B lyphocytes are considered part of the adaptive immunity?

a they produce memory cell when activated b their receptors will bind to only one antigen c they require costimulation from an activated T helper cell d thet are a first line of defense that can begin killing

6. Over lap in the innate and adaptive immune sys is seen in all of the following examples but one Which of the following examples does NOT illustrate the over lap of innate and adaptive immune resposes ??? adendritic cell presenting antigen on their MHC II proteins to T helper cells b macrophage becoming activated macrophages in response to cytokines realesed by T helper cells c natural killer cell causing of an abnoraml host cell lacking MHC proteins d Plasma cell that produce large amounts of IgE that will ultimetly allow mast cell to relase histamine

7. Which of the following examples below describe an autoimmune disease? a infection and death of T helper cells bya virus resulting in a loss of adaptive immunity b realse of bacterial endotoxins that block acetylcholine realse result is muscle paralysis c antibody binding to acetylcholine receptors of hte motor end palte resulting in muscle weakness.d uncontrolled cell division resulting in cell surface abnormalities recognized by natural killer cell.

8. Which of he following does NOT describe actions of interferon IFN? a virally infected cell can release interferon which attracts natural killer cell to attack and kill the IFN secreting cell b IFN binds to normal uninfected cell stimulating the activation of genes that produce anti viral proteins c IFN will attract macrophages to the secreting cell to be removed bt phagocytosis d IFN can penetrate the virla capsid and destroy the virus