MBG 4020 Lecture Notes - Lecture 13: Silent Mutation, Genotyping, Planning Horizon

• School: University of Guelph
• Department: Molecular Biology and Genetics
• Course: MBG 4020
• Professor: Andrew Robinson

Document Summary

Find a polymorphism in the genome that is associated with a distinct difference in phenotype. The concept is simple but the execution can get complicated. Qtl detection steps: find a marker or many markers, genotype a population for the markers, use sta to associate marker genotypes with differences in phenotypes, test on another population (if possible) Need polymorphisms (alleles) within the region of the genome that is of interest. Molecular genetic tools used to find these polymorphisms. A and a are new marker alleles at a marker locus. We only need a marker loci to be able to do selection. It is very expensive to track them down. Look for statistical association between the marker genotype and differences in genotype. P value= how willing we are to be wrong for that conclusion. Towns that have more people will have more churches and more pubs so that statistical correlation between increased churches and increased pubs.