MBG 4020 Lecture 9: Ethics
16 Nov 2016
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Document Summary
Sequence homology with humans/ mice/ cattle etc. Vaccines that target host/ pathogen gene interaction. Drugs that enhance host/ cell/ tissue/ organ response. Speci c look at traits (mostly) unique to companion animals. Dimitri belayev: long-term experiment in selection for docility. Positive response to human (wag tail, whine) Kits earlier to open their eyes and respond to sound. Delayed development of fear response ( change in glucocorticoids) Higher levels of serotonin in the brain. Similar responses to domestication in other species. 36 genome regions showed selection changes in dogs compared to wolves. 10 for starch digestion and fat metabolism. Colour behave differently in various breeds not everything is gured out yet, Fawn, sable, black and tan or all black. Hormone housekeeping is similar in all three. Altered expression of neuropeptide calcb and npy in dogs. Nhlrcl associated with epileptiform seizures in daschunds. Arti cial selection for preferred behaviours for breed type. Herding dogs- play behaviours translate into herding.
