BIOL 1090 Lecture Notes - Lecture 8: Start Codon, Zinc Finger, Hbb
8 Apr 2016
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Document Summary
Mutaions can arise spontaneously as a result of an error during dna synthesis. Incorporaion of rare isoforms of the four bases that have altered base pairing properies. The nitrogenous bases of dna exist in two isoforms (tautomers) The rare isoforms have altered base pairing properies. Incorporaion of a rare isoform during dna replicaion can lead to a change in dna sequence. Somaic mutaions may afect the individual in which they occur in dramaic ways, but will not be passed on. While the occurrence of mutaions is largely random, their efects are not. Germ line mutations (ex. during the mitoic divisions of spermatogonia or in the s phase that precedes meiosis) will be inherited. Hot spots for spontaneous mutaions during dna replicaion. Mutaions can also be induced by exposure to chemical mutagens. Chemical mutagens can be divided into 2 groups: those that are mutagenic only to replicaing dna. Acridine dyes: those that are mutagenic to both replicaing and non-replicaing dna.
