BIOL 1090 Lecture Notes - Lecture 7: Solution, Defence Mechanisms, Endocytosis

• School: University of Guelph
• Department: Biology
• Course: BIOL 1090
• Professor: Andrew Bendall

Document Summary

Amino acid sequence that directs protein back to er=er retrieval signal. Soluble/luminal er proteins contain kdel(lysine-asparic acid-glutamic acid-leucine) retrieval signal. Kdel receptors in membranes of cgn and cis golgi bind to retrieval signal of escaped proteins. Kdel receptors bind to copi complex proteins and are incorporated into copi vesicles. Escaped proteins reach the er in (copi-coated) retrograde transport vesicles. Composed of 3 heavy and 3 light chains. Triskelions interact-polyhedral laice, a basket like structure that surrounds a vesicle. Ccv: adaptor proteins between clathrin laice and the cytosolic face of the vesicle. Selecively sort cargo at tgn, cell membrane and endosomal compartments. Electrion micrographs: sequence of events in the formaion of a ccv at the surface of the plasma membrane. The cargo receptors extend through the membrane and interact with cargo molecules in the cytoplasm. As the process coninues, the vesicles round up and pinch of.