BIOL 1080 Lecture Notes - Lecture 18: Interleukin 6, Dna Replication, Mitochondrion
Document Summary
Damage in mitochondrial dna that encodes to mitochondrial protein (used for etc) Polymorphism: when order of dna expression switch. Snps occur in the non coding regions of dna (promoters) This alter the code in promoter region but changes of the amount of protein you make (either more or less) 1 in every 300 nucleotides there is a snps. The more il-6 the shorter you live (correlationship) Mitochondria contains gene components of the etc. Accumulate mutations in mitochondrial dna and accelerates aging errors in replication. Damage mitochondrial genome occurs 10x more frequently than the nuclear genome due to the generation of reactive oxygen species (ros) Every now and then, a single electron comes off. Because they are not paired they are very reactive - free radicals (eg. with dna, lipids or proteins) this damages the things they react with. Damage dna cause mutation and form mutated protein. During old age, dna replication has more errors.
