BIOL 435 Lecture 22: Lecture 22 Notes
10 Dec 2015
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Gynandromorphic flies (one side is one sex and other side is different sex) Not all genes on x ch (barr body) is inactivated; some remain active. Biol 442 developmental biology: therefore, sex is determined by the y chromosome, hypothesis: there must be a sex determining factor on the chromosome (this factor is called the testis determining factor) By analyzing the dna of rare xx men and xy (cid:252) mapping the testis determining factor (tdf) women, the position of the tdf was identified on the. Tdf is located near the tip of the short arm (cid:252) sry (sex-determining region of the y) is the gene that. Sry transgene can transform xx mouse => male: genetics of primary sex determination in humans (cid:252) sry = account for only 20% of human xy sex reversal (cid:252) sox9 = Individuals heterozygous for sox9 (sox9 -/+) have campomelic dysplasia: 75% of xy individuals phenotypically female. Sox9 expression is sufficient for testis development in.
