PMCOL305 Lecture Notes - Lecture 11: Xanthine, Adenosine, Basal Forebrain
11 Oct 2016
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Learn what nootropics are and why they are used. Major sources coffee, tea, chocolate, soft drinks, e drinks, otc drugs. Produces similar but milder effects as classic psychostimulants (cocaine, amphetamine) Motor activation, arousal, increased [ ] and wakefulness. Xanthine backbone with a few methyl groups attached. All mimics circled adenosine structure and binds to similar rs. So(cid:373)e (cid:272)o(cid:373)pa(cid:374)ies (cid:272)lai(cid:373) that they use a(cid:374) (cid:862)orga(cid:374)i(cid:272)(cid:863) alter(cid:374)ati(cid:448)e to (cid:272)affei(cid:374)e. Is chemically identical to caffeine but comes from diff sources yerba mate and guarana plants. Health canada has almost no restrictions on guaranine content in drinks; companies exploit this. Increases release of nts including adrenaline arousal and anxiety. Dilation of bvs in periphery but constriction of cranial vessels (headache treatment) Bp effects are complicated b/c it acts locally on bvs (dilation) and centrally in brain (constrict) Relaxation of smooth muscle, stim of skeletal muscle.
